Best Cold Sore Cream

Cold sores also known as fever blisters are a chronic and therefore recurring disease. Once outbreaked, the virus remains active in the body for a lifetime and can emerge at any time, at regular or irregular intervals. Patients often report that cold sores occur regularly and at the same time of year. To shorten the duration of herpes, it is important to use the best cold sore treatment for each individual. In our buying guide, we would like to help you find the best cold sore cream.

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Cold sore infection

Most often, the annoying blisters appear with a tingling sensation. Subsequently, the famous cold sore develops bacterial fluid, which urgently must not spread further!

The initial infection usually occurs in childhood. Often, this happens through sharing dishes or even sharing food, with an already infected child. Subsequently, viral transmission may have occurred, but whether the cold sore virus also occurs in the future is not said.

Possible triggers for the development of the small blisters include stress and a weak immune system. In general, however, it should be mentioned that the trigger is also caused as a result of fever or excessive UV radiation.

Possible triggers for the development of the small blisters include stress and a weak immune system. In general, however, it should be mentioned that the trigger is also caused as a result of fever or excessive UV radiation.


The skin on the lips is very thin, to avoid an outbreak of cold sores it is advisable to pay special attention to lip care and use protective creams especially in the first period of spring sunshine.

Occurrence of cold sores

Stage Description

Stage 1: The first thing sufferers feel is a tingling sensation on the skin around the lip. This is the first sign that herpes is breaking out. After that, the affected area reddens and a small blister forms, which is filled with fluid.

Stage 2: The vesicle becomes larger and loses fluid. The wound only tingles occasionally, causes a feeling of tension and hurts a little. This is the particularly contagious phase, so it is advisable not to touch the wound under any circumstances. Pay special attention to good hygiene and wash your hands regularly, especially if you accidentally touch the affected area.

Stage 3: A dry crust or scab forms over the blisters. Once this occurs, you are no longer contagious, it is just a wound that needs to heal. You should treat the blister regularly with herpes cream to prevent it from rupturing and to ensure quick healing.


Note: Especially during Stage 2, try to keep the wound as dry as possible to prevent unnecessary further fluid build-up that could slow regeneration and cause another outbreak. 

The best cold sore cream for appropriate treatment

The best cold sore creams should usually consist of antiviral ingredients, such as acyclovir, penciclovir or docosanol. It is also advisable to use products that contain additional oxides and anti-itch agents to ensure successful treatment. Among the best cold sore treatment products are those from the brands Abreva and Zilactin. However, it should be mentioned that the creams only produce a shortening of the symptoms and are best appealed and effective with early application.


The total treatment can last from 3 to 5 days if the products are used correctly. However, in individual and severe cases and with no or poor treatment, the process can drag on up to 2 weeks and longer.

The best over the counter cold sore cream ingredients


Acyclovir is a very common, medicinal ingredient that is present in both the best cold sore creams and tablets. This can be purchased in any pharmacy and mostly in supermarkets and on the Internet without a prescription. It should be mentioned that especially pregnant women should not use this active ingredient.


Another antiviral ingredient for the best cold sore treatment is penciclovir. This can only be purchased as a cream and, like the active ingredient acyclovir, is available over the counter.

Alternatives to the best cold sore creams

There are several alternatives to cold sore creams that can provide relief and aid in the healing process. Red light therapy is a non-invasive treatment option that utilizes low-level light to stimulate healing and reduce pain associated with cold sores. Cold sore patches are adhesive patches that cover the cold sore, creating a protective barrier and promoting faster healing. Additionally, oral antiviral medications prescribed by a healthcare professional can help reduce the duration and severity of cold sores, especially for recurrent outbreaks. It’s important to consult with a healthcare provider to determine the most suitable alternative for your specific situation.

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I'm Sophie, an undergraduate studying Marketing with a keen interest in drugstore products. Through my writing, I explore the vast world of affordable beauty and personal care items. I provide honest reviews and recommendations, guiding readers to discover quality products that fit their budget and enhance their self-care routines.